Biograph RT Pro edition

Imaging for the right plan

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Biograph™ RT Pro edition is a comprehensive PET/CT solution designed specifically for radiotherapy treatment planning. For nuclear medicine departments looking to efficiently expand their services into radiation oncology departments or for dedicated radiation oncology departments that want to advance their in-department imaging, the Biograph RT Pro edition provides clinicians a precise image for more effective therapy planning.

Built upon the premium PET and CT technologies of Siemens Biograph mCT family of large bore scanners, it offers the finest volumetric PET resolution* and provides excellent temporal and high contrast CT resolution required to enhance tumor boundary definition for sharper delineation of gross tumor volumes, allowing clinicians to devise treatment strategies with confidence. With the premium PET and CT technologies, Biograph RT Pro edition can be used to perform PET/CT simulations or CT simulations.

Evolving PET/CT Utilization

Modern radiotherapy delivers higher doses to more targeted areas of the tumor, resulting in a need for greater planning precision with increased reliance on the ability of PET/CT imaging to visualize both metabolic and anatomical information.

Making a Difference in RT Planning with PET/CT

»In 80% of head and neck cases, the PET/CT GTV contour was smaller than CT alone.«   Disclaimer

Delouya, G., et al. … imaging in radiotherapy tumor volume delineation in treatment of head and neck cancer. Radiotherapy and Oncology 101 ((2011) 362-368

Head and neck cancers account for approximately 3-5% of cancer in the United States with an approximate annual incidence of 45,000 cases annually. Critical structures for the head and neck region include: spinal cord, brainstem, parotid glands, larynx and esophagus.


Biograph mCT

Making a difference in radiation therapy planning for head and neck cancer

Threshold-based contour of primary tumor

Colorwash images of the dose distribution plan

Post-radiation therapy PET/CT

SUVmax threshold-based tumor ROIs were contoured and exported to TPS. The dose plan shown delivered a high dose level to the primary tumor and the location of the initial lymph node. A second PET/CT performed 3 months after the completion of radiotherapy showed no sign of residual or recurrent tumor.

Examination Protocol: Scanner: Biograph mCT 128; injected dose: 10 mCi CT: 70 eff mAs, kV 130

Courtesy of Rigshospitalet,
Copenhagen, Denmark

»Potential to improve radiation therapy planning by allowing for the tailoring of comprehensive radiation portals, particularly for locally advanced or recurrent breast cancer, makes it one of the most promising tools in the era of image-guided radiation therapy.«   Disclaimer

Beriwal Sushil, MD, PET/CT in Radiation Therapy for Breast Cancer, PET Clinics, Volume 4, Issue 4, October 2009, Pages 349-357

Breast cancer is the most common type of cancer in American women, with approximately 231,840 women 2,350 men diagnosed annually.


Biograph mCT

Making a difference in radiation therapy planning for breast cancer

Utilization of PET/CT data in the radiation treatment process enables the visualization of the hypermetabolic lesion and metastases in this recurrent breast cancer case supporting use of image guided radiation therapy to tailor comprehensive radiation portals.

Examination Protocol: Scanner: Biograph mCT 40; injected dose: 208 MBq, 60 minute uptake, 3 minutes per bed, TrueV and UltraHD•PET CT: low dose for attenuation

Courtesy of Groene Hart Ziekenhuis, PET/CT Centrum West Netherland, Gouda, Netherlands

»PET/CT altered radiation therapy planning in over 50% of lung cancer cases.«   Disclaimer

Bradley, J. MD., et al. Impact of … on radiation therapy volume delineation in non-small cell lung cancer. Int. J. Radiation Oncology Biol. Phys., Vol. 59, No.1, pp. 78-86, 2004.

Lung cancer is one of the leading causes of cancer deaths in the United States, among both men and women. Approximately 221,200 Americans will be diagnosed with lung cancer this year.


Biograph mCT

Making a difference in radiation therapy planning for lung cancer

Standard Radiation Dose Protocol

Standard conformal radiation therapy (CRT) dose colorwash for the lung tumor base on CT

Dose Escalation Protocol

RT dose distribution for same lung lesion with dose escalation strategy aiming to give 130% of dose to the region of the tumor with the highest glucose avidity

Source: Imaging Life, Issue 07, Pg. 62

Images courtesy of University of Tennessee,
Knoxville, TN, USA

»Patients treated with PET/CT-guided IMRT have improved survival and less treatment toxicity.«

Kidd, Elizabeth, MD, et al., Clinical Outcomes of Definitive Intensity-Modulated Radiation Therapy with …Simulation in Patients with Locally Advanced Cervical Cancer. Int. J. Radiation Oncology biol. Phys., Vol. 77, No.4, pp. 1085-1091, 2010. Disclaimer

Approximately 12,900 new cases of invasive cervical will be diagnosed in 2015 and about 4,100 women will die from cervical cancer in 2015.


Biograph mCT

Making a difference in radiation therapy planning for cervical cancer

RapidArc therapy plan for primary cervical tumor with pelvic and para-aortic nodal irradiation based on Biograph mCT PET/CT images. The planned targets were treated with up to 50.47 Gy over 28 fractions by RapidArc technique with image-guided setup.

Image courtesy of Chang Gung Memorial Hospital,
Linkou, Taiwan

»In general, when a recurrence is suspected after the primary treatment (either radical prostatectomy or radiotherapy), PET/CT could be suggested as the first procedure in re-staging prostate cancer to guide further treatment decisions.«   Disclaimer

Picchio, Maria, et al. Clinical evidence on PET/CT for radiation therapy planning in prostate cancer. Radiotherapy and Oncology 96 (2010) 347-350.

Carcinoma of the prostate is the most commonly occurring cancer in men. This year, in excess of 200,000 new cases of prostate will be diagnosed in the united states alone. The American Cancer Society estimates that one in every six men will develop prostate cancer in his lifetime.


Biograph mCT

Making a difference in radiation therapy planning for prostate cancer

Intense tracer accumulation in the right prostatic lobe and metastatic lesions in the right pelvic region from the PET/CT data supports the radiotherapy target volume determination for this patient with recurrent prostate cancer.

Examination Protocol: Scanner: Biograph 16 ; injected dose: 740 MBq, 4 minutes per bed CT: low dose for attenuation

Courtesy of University Hospital Muenster,
Germany, Prof. Dr. Dr. O. Schober


Hear from the experts

»We feel safer doing tumor delineation when it is performed with biograph mCT. It couldn’t be more precise. We are defining smaller gross tumor margins, because we are highly certain about the accuracy of our margins.«   Disclaimer

»So that’s 15 percent of patients whose treatment plans change as a result of the PET/CT images.«

Anne Kill Berthelsen, MD, Chief Radiologst, Rigshospitalet, Copenhagen University Hospital
Copenhagen, Denmark

»All those image quality characteristics will help us create carefully sculpted, highly focused plans.«

Billy W. Loo, Jr., MD, PhD Stanford Medical Center Stanford, CA, USA Disclaimer

Flexible Workflow

Biograph RT Pro edition is a large bore PET/CT system with the flexibility to perform PET/CT simulations or CT simulations. Built upon the Siemens SOMATOM™ Definition CT platform, the Biograph RT Pro edition provides excellent temporal and high contrast resolution needed for radiation therapy planning.

syngo™.via provides many flexible software options that can be tailored to accommodate various clinical and workflow needs. From image assessment to basic GTV contouring, syngo.via offers a solution that allows you to asses images and share them with the appropriate department in either a DICOM or DICOM RT structure set.

syngo.via RT Image Suite, a dedicated multimodality software for radiation oncology, supports streamlined workflows leading to increased performance and outcomes. syngo.via RT Image Suite opens up advanced imaging and contouring capabilities to clinical users of all levels of expertise, allowing the user to export DICOM standard compliant structures to treatment planning systems.

syngo.via software provides a seamless workflow to your treatment planning system, allowing you to calculate dose in your treatment planning system environment.

PET/CT is the emerging standard in treatment planning where modern radiotherapy and radiosurgery require delivering higher doses to smaller areas., such as in SBRT or IMRT.

Built for Radiation Therapy

High resolution images for precise tumor delineation
Manage motion for precise therapy planning
Help ensure precise image registration for accurate contouring
Help ensure accurate and reproducible patient positioning
Improve image quality for more precise tumor delineation
Accommodate virtually all patients*
See a more complete clinical picture

High-resolution Matrix

Finest details with 400x400 reconstruction matrix*

Conventional 256x256 Matrix

  • 256x256 interpolated reconstruction
  • 256x256 reconstruction may miss small lesions with low contrast due to partial volume effects

Siemens Hi-Rez Matrix

  • 400x400 direct reconstruction matrix increases NEMA resolution by up to 25% over the 256x256 matrix
  • Enables physicians to see the finest detail*
  • Enables precise tumor contouring for treatment planning

Open gating interface for different vendors

SMART Patient Handling System (PHS)

Removes differential deflection

Conventional Table Design

Siemens SMART Patient Handling System

  • Floating table design allows for pallet deflection
  • Potential for inaccuracy of PET and CT registration, which could affect attenuation correction

  • Unique cantilevered design removes differential deflection
  • Correct registration of PET and CT for accurate attenuation correction
  • TG-66 compliant for RT


Reduce metal artifacts in various body regions

Metal artifact reduction

Biograph mCT with iMAR* reduces metal artifacts in various body regions. iMAR is designed to yield images with a reduced level of metal artifacts compared to conventional reconstruction if the underlying CT data is distorted by metal being present in the scanned object.

Large 78 cm Bore

Accommodates radiation therapy positioning devices

HD Field of View Pro

Improved consistency throughout the field-of-view

Challenging bariatric pelvic case (70 cm patient width)

  • < 50 cm scan Field of View
    Pro Full reconstruction
  • > 50 cm–78 cm HD Field of View Pro
    Designed to enable a more reliable visualization of body outline located outside of the diagnostic field of view

  1. Fiducials clearly imaged >10 cm outside sFoV
  2. HU units consistent inside and outside the sFoV
  3. Contours closed on both sides