Biograph™ RT Pro edition is a comprehensive PET/CT solution designed specifically for radiotherapy treatment planning. For nuclear medicine departments looking to efficiently expand their services into radiation oncology departments or for dedicated radiation oncology departments that want to advance their in-department imaging, the Biograph RT Pro edition provides clinicians a precise image for more effective therapy planning.
Modern radiotherapy delivers higher doses to more targeted areas of the tumor, resulting in a need for greater planning precision with increased reliance on the ability of PET/CT imaging to visualize both metabolic and anatomical information.
»In 80% of head and neck cases, the PET/CT GTV contour was smaller than CT alone.« DisclaimerDelouya, G., et al. … imaging in radiotherapy tumor volume delineation in treatment of head and neck cancer. Radiotherapy and Oncology 101 ((2011) 362-368
Head and neck cancers account for approximately 3-5% of cancer in the United States with an approximate annual incidence of 45,000 cases annually. Critical structures for the head and neck region include: spinal cord, brainstem, parotid glands, larynx and esophagus.
Making a difference in radiation therapy planning for head and neck cancer
Threshold-based contour of primary tumor
Colorwash images of the dose distribution plan
Post-radiation therapy PET/CT
SUVmax threshold-based tumor ROIs were contoured and exported to TPS. The dose plan shown delivered a high dose level to the primary tumor and the location of the initial lymph node. A second PET/CT performed 3 months after the completion of radiotherapy showed no sign of residual or recurrent tumor.
Examination Protocol: Scanner: Biograph mCT 128; injected dose: 10 mCi CT: 70 eff mAs, kV 130
Courtesy of Rigshospitalet,
»Potential to improve radiation therapy planning by allowing for the tailoring of comprehensive radiation portals, particularly for locally advanced or recurrent breast cancer, makes it one of the most promising tools in the era of image-guided radiation therapy.« DisclaimerBeriwal Sushil, MD, PET/CT in Radiation Therapy for Breast Cancer, PET Clinics, Volume 4, Issue 4, October 2009, Pages 349-357
Breast cancer is the most common type of cancer in American women, with approximately 231,840 women 2,350 men diagnosed annually.
Making a difference in radiation therapy planning for breast cancer
Utilization of PET/CT data in the radiation treatment process enables the visualization of the hypermetabolic lesion and metastases in this recurrent breast cancer case supporting use of image guided radiation therapy to tailor comprehensive radiation portals.
Examination Protocol: Scanner: Biograph mCT 40; injected dose: 208 MBq, 60 minute uptake, 3 minutes per bed, TrueV and UltraHD•PET CT: low dose for attenuation
Courtesy of Groene Hart Ziekenhuis, PET/CT Centrum West Netherland, Gouda, Netherlands
»PET/CT altered radiation therapy planning in over 50% of lung cancer cases.« DisclaimerBradley, J. MD., et al. Impact of … on radiation therapy volume delineation in non-small cell lung cancer. Int. J. Radiation Oncology Biol. Phys., Vol. 59, No.1, pp. 78-86, 2004.
Lung cancer is one of the leading causes of cancer deaths in the United States, among both men and women. Approximately 221,200 Americans will be diagnosed with lung cancer this year.
Making a difference in radiation therapy planning for lung cancer
Standard conformal radiation therapy (CRT) dose colorwash for the lung tumor base on CT
RT dose distribution for same lung lesion with dose escalation strategy aiming to give 130% of dose to the region of the tumor with the highest glucose avidity
Source: Imaging Life, Issue 07, Pg. 62
Images courtesy of University of Tennessee,
Knoxville, TN, USA
»Patients treated with PET/CT-guided IMRT have improved survival and less treatment toxicity.«Kidd, Elizabeth, MD, et al., Clinical Outcomes of Definitive Intensity-Modulated Radiation Therapy with …Simulation in Patients with Locally Advanced Cervical Cancer. Int. J. Radiation Oncology biol. Phys., Vol. 77, No.4, pp. 1085-1091, 2010. Disclaimer
Approximately 12,900 new cases of invasive cervical will be diagnosed in 2015 and about 4,100 women will die from cervical cancer in 2015.
Making a difference in radiation therapy planning for cervical cancer
RapidArc therapy plan for primary cervical tumor with pelvic and para-aortic nodal irradiation based on Biograph mCT PET/CT images. The planned targets were treated with up to 50.47 Gy over 28 fractions by RapidArc technique with image-guided setup.
Image courtesy of Chang Gung Memorial Hospital,
»In general, when a recurrence is suspected after the primary treatment (either radical prostatectomy or radiotherapy), PET/CT could be suggested as the first procedure in re-staging prostate cancer to guide further treatment decisions.« DisclaimerPicchio, Maria, et al. Clinical evidence on PET/CT for radiation therapy planning in prostate cancer. Radiotherapy and Oncology 96 (2010) 347-350.
Carcinoma of the prostate is the most commonly occurring cancer in men. This year, in excess of 200,000 new cases of prostate will be diagnosed in the united states alone. The American Cancer Society estimates that one in every six men will develop prostate cancer in his lifetime.
Making a difference in radiation therapy planning for prostate cancer
Intense tracer accumulation in the right prostatic lobe and metastatic lesions in the right pelvic region from the PET/CT data supports the radiotherapy target volume determination for this patient with recurrent prostate cancer.
Examination Protocol: Scanner: Biograph 16 ; injected dose: 740 MBq, 4 minutes per bed CT: low dose for attenuation
Courtesy of University Hospital Muenster,
Germany, Prof. Dr. Dr. O. Schober
»We feel safer doing tumor delineation when it is performed with biograph mCT. It couldn’t be more precise. We are defining smaller gross tumor margins, because we are highly certain about the accuracy of our margins.« Disclaimer
»So that’s 15 percent of patients whose treatment plans change as a result of the PET/CT images.«
Anne Kill Berthelsen, MD, Chief Radiologst, Rigshospitalet, Copenhagen University Hospital
»All those image quality characteristics will help us create carefully sculpted, highly focused plans.«Billy W. Loo, Jr., MD, PhD Stanford Medical Center Stanford, CA, USA Disclaimer
Biograph RT Pro edition is a large bore PET/CT system with the flexibility to perform PET/CT simulations or CT simulations. Built upon the Siemens SOMATOM™ Definition CT platform, the Biograph RT Pro edition provides excellent temporal and high contrast resolution needed for radiation therapy planning.
syngo™.via provides many flexible software options that can be tailored to accommodate various clinical and workflow needs. From image assessment to basic GTV contouring, syngo.via offers a solution that allows you to asses images and share them with the appropriate department in either a DICOM or DICOM RT structure set.
syngo.via RT Image Suite, a dedicated multimodality software for radiation oncology, supports streamlined workflows leading to increased performance and outcomes. syngo.via RT Image Suite opens up advanced imaging and contouring capabilities to clinical users of all levels of expertise, allowing the user to export DICOM standard compliant structures to treatment planning systems.
syngo.via software provides a seamless workflow to your treatment planning system, allowing you to calculate dose in your treatment planning system environment.
PET/CT is the emerging standard in treatment planning where modern radiotherapy and radiosurgery require delivering higher doses to smaller areas., such as in SBRT or IMRT.
Biograph mCT with iMAR* reduces metal artifacts in various body regions. iMAR is designed to yield images with a reduced level of metal artifacts compared to conventional reconstruction if the underlying CT data is distorted by metal being present in the scanned object.