Cardiac Troponin Assays

for Earlier Diagnosis of Myocardial Infarctions

Cardiac Troponin Assays
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ADVIA Centaur High-Sensitivity Troponin I Assay

High-Sensitivity Troponin I is the latest addition to Siemens Healthineers’ comprehensive cardiac menu to assist clinicians with the diagnosis and treatment of chest pain patients. Designed to aid in diagnosing acute myocardial infarctions (AMI) through the quantitative measurement of cardiac troponin I in serum or plasma, high-sensitivity troponin plays a critical role in the timely diagnosis of AMI, or heart attacks.

The ADVIA Centaur® High-Sensitivity Troponin I* (TNIH) assay is a true high-sensitivity assay.

  • Offers improved cardiac patient care with a high-sensitivity troponin assay that meets current European Society of Cardiology clinical guidelines
  • Provides fast, accurate and actionable test results allow clinicians to confidently rule in/rule out a myocardial infarction when triaging patients with chest pain
  • Ensures reliable results from a proven, trusted technology coupled with three new monoclonal antibodies

Compared to traditional troponin assays, the Siemens Healthineers ADVIA Centaur TNIH assay is able to detect lower levels of troponin and smaller changes to a patient’s troponin levels, which may be an early indication of AMI. This design affords clinicians greater confidence in patient results at the low end of the assay range by delivering precision that provides the ability to measure slight, yet critical, changes between serial troponin I values.

Precision at the low end is important to minimize analytic variation that could confuse a clinician’s assessment of a clinically significant change. With this data in hand, clinicians have the ability to more quickly diagnose and treat patients with suspected AMI, in some cases in as little as one to three hours.

Download the new white paper provides performance data on the ADVIA Centaur High-Sensitivity Troponin I assay


Assay Specifications

ADVIA Centaur High-Sensitivity Troponin I* Assay Performance Summary

Sample TypeHuman serum, plasma (lithium heparin)
Sample Volume100 µL
Assay Range2.50 – 25,000.00 pg/mL (ng/L)
Time to First ResultXP/XPT: 18 minutes
ThroughputUp to 240 tests/hour
On-board Stability28 days
Calibration Interval14 days
LoB0.90 pg/mL (ng/L)
LoD2.21 pg/mL (ng/L)
LoQ (20% CV)2.50 pg/mL (ng/L)
LoQ (10% CV)4.50 pg/mL (ng/L)
99th Percentile47.34 ng/L (pg/mL)ǂ


Cardiac Menu

Centaur® Systems
IMMULITE® SystemsDimension® EXL™ Systems

Vista Systems

Stratus® CS Systems
BNP       √      
CKMB Mass       √        √        √        √      √
CKMB Isoenzyme          √        √ 
D-Dimer         √          √
Galectin-3       √*      
High-Sensitivity CRP          √        √        √      √
High-Sensitivity Troponin I1
       √§          √*        √*  
Myoglobin       √        √        √        √      √
NT-proBNP       √*          √        √      √
Tnl-Ultra™       √ǂ        
Troponin I          √        √ǂ        √ǂ      √ǂ


Assay availability may vary from country to country and subject to local regulatory requirements
*Under development. Not available for sale.
§Not available for sale in the U.S.
1. Available on the ADVIA Centaur XP and XPT Systems only

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The products/features (mentioned herein) are not commercially available in all countries. Due to regulatory reasons their future availability cannot be guaranteed. Please contact your local Siemens Healthineers organization for further details.