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Bone Metabolism

In the past decades, the global incidence of osteoporosis has increased dramatically with rising life expectancy, and over 200 million people suffer from osteoporosis worldwide. By 2050, the global cost of osteoporosis is expected to exceed $130 billion and the annual hip fracture incidence is expected to increase to 6.3 million.1,2 The highest risk of hip fractures are currently found in Norway, Sweden, Iceland, Denmark, and the United States, but by 2050 Asia is expected to account for almost one-half of all global fractures.3,4




1 Reginster JY, Burlet N. Osteoporosis: A still increasing prevalence. Bone. 2006 Feb;38(2 Suppl 1):S4-9.

2 Johnell O. The socioeconomic burden of fractures: today and in the 21st century. Am J Med. 1997 Aug 18;103(2A):20S-25S; discussion 25S-26S.

3 Kanis JA, Johnell O, De Laet C, Jonsson B, Oden A, Ogelsby AK. International variations in hip fracture probabilities: implications for risk assessment. J Bone Miner Res. 2002 Jul;17(7):1237-44.

4 Gullberg B, Johnell O, Kanis JA World-wide projections for hip fracture. Osteoporosis Int. 1997;7(5):407-13.

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